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Article

Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor.

Science (New York, N.Y.) - 8 Feb 2002

Di Croce Luciano, Raker Veronica A, Corsaro Massimo, Fazi Francesco, Fanelli Mirco, Faretta Mario, Fuks Francois, Lo Coco Francesco, Kouzarides Tony, Nervi Clara, Minucci Saverio, Pelicci Pier Giuseppe

Abstract excerpt

DNA methylation of tumor suppressor genes is a frequent mechanism of transcriptional silencing in cancer. The molecular mechanisms underlying the specificity of methylation are unknown. We report here that the leukemia-promoting PML-RAR fusion protein induces gene hypermethylation and silencing by recruiting DNA methyltransferases to target promoters and that hypermethylation contributes to its leukemogenic...

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Identifiers

PMID: 11834837
DOI: 10.1126/science.1065173

Genes

PML

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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