Article
DNA methylation changes are a late event in acute promyelocytic leukemia and coincide with loss of transcription factor binding.
Blood - 3 Jan 2013
Schoofs Till, Rohde Christian, Hebestreit Katja, Klein Hans-Ulrich, Göllner Stefanie, Schulze Isabell, Lerdrup Mads, Dietrich Nikolaj, Agrawal-Singh Shuchi, Witten Anika, Stoll Monika, Lengfelder Eva, Hofmann Wolf-Karsten, Schlenke Peter, Büchner Thomas, Hansen Klaus, Berdel Wolfgang E, Rosenbauer Frank, Dugas Martin, Müller-Tidow Carsten
Abstract excerpt
The origin of aberrant DNA methylation in cancer remains largely unknown. In the present study, we elucidated the DNA methylome in primary acute promyelocytic leukemia (APL) and the role of promyelocytic leukemia-retinoic acid receptor α (PML-RARα) in establishing these patterns. Cells from APL patients showed increased genome-wide DNA methylation with higher variability than healthy CD34(+) cells, promyelocytes,...
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