Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA methylation-independent loss of RARA gene expression in acute myeloid leukemia

10 Nov 2007

Abstract excerpt

The retinoic acid receptor (RAR) alpha gene (RARA) encodes 2 major isoforms and mediates positive effects of all-trans retinoic acid (ATRA) on myelomonocytic differentiation. Expression of the ATRA-inducible (RARalpha2) isoform increases with myelomonocytic differentiation and appears to be down-regulated in many acute myeloid leukemia (AML) cell lines. Here, we demonstrate that relative to normal myeloid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Epigenetics and DNA Methylation
Share to Retinoids in leukemia and cellular processes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17993618
DOI: 10.1182/blood-2007-05-088344

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA methylation-independent loss of RARA gene expression in acute myeloid leukemiaPMID 17993618Read ↗

Retinoic acid receptors, hematopoiesis and leukemogenesisSemantic proximity Read ↗

DNA methylation changes are a late event in acute promyelocytic leukemia and coincide with loss of transcription factor binding.Semantic proximity Read ↗

Retinoic acid receptor alpha (RAralpha) Mutations in Human Leukemia.Semantic proximity Read ↗

ASB-2 Inhibits Growth and Promotes Commitment in Myeloid Leukemia CellsSemantic proximity Read ↗

Acute Promyelocytic Leukemia: Update on the Mechanisms of Leukemogenesis, Resistance and on Innovative Treatment StrategiesSemantic proximity Read ↗

Retinoic acid signaling in cancer: The parable of acute promyelocytic leukemiaSemantic proximity Read ↗

ATRA Resistance in Acute Promyelocytic Leukemia: Mechanisms Unveiled, Therapies ReimaginedSemantic proximity Read ↗

The transcriptional corepressor CBFA2T3 inhibits all-trans-retinoic acid–induced myeloid gene expression and differentiation in acute myeloid leukemiaSemantic proximity Read ↗

Tumor suppressor function of Gata2 in acute promyelocytic leukemia.Semantic proximity Read ↗

RARA and RARG gene downregulation associated with EZH2 mutation in acute promyelocytic-like morphology leukemia.Semantic proximity Read ↗

Impaired retinoic acid (RA) signal leads to RARbeta2 epigenetic silencing and RA resistance.Semantic proximity Read ↗

Altered ligand binding and transcriptional regulation by mutations in the PML/RARα ligand-binding domain arising in retinoic acid–resistant patients with acute promyelocytic leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.