Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional regulation in acute promyelocytic leukemia.

Oncogene - 29 Oct 2001

Lin R J, Sternsdorf T, Tini M, Evans R M

Abstract excerpt

It has been 10 years since the seminal discovery that a mutant form of a retinoid acid receptor (RARalpha) is associated with acute promyelocytic leukemia (APL). This finding, coupled with the remarkable success of retinoic acid (RA), the natural ligand of RARalpha, in the treatment of APL, has made APL a unique model system in the study of oncogenic conversion of transcription factors in hematological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation, Leukemic
Share to Kruppel-Like Transcription Factors
Share to Leukemia, Promyelocytic, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oncogene Proteins, Fusion

Share to Organelles

Share to Promyelocytic Leukemia Protein

Share to Receptors, Retinoic Acid

Share to Retinoic Acid Receptor alpha

Source

Identifiers

PMID: 11704848
DOI: 10.1038/sj.onc.1204853

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional regulation in acute promyelocytic leukemia.PMID 11704848Read ↗

Molecular genetics of acute promyelocytic leukemia.Semantic proximity Read ↗

Retinoic acid signaling in cancer: The parable of acute promyelocytic leukemiaSemantic proximity Read ↗

Retinoic acid receptors, hematopoiesis and leukemogenesisSemantic proximity Read ↗

Retinoic acid receptor alpha (RAralpha) Mutations in Human Leukemia.Semantic proximity Read ↗

Altered ligand binding and transcriptional regulation by mutations in the PML/RARα ligand-binding domain arising in retinoic acid–resistant patients with acute promyelocytic leukemiaSemantic proximity Read ↗

The role of promyelocytic leukemia zinc finger and promyelocytic leukemia in leukemogenesis and developmentSemantic proximity Read ↗

Oncogenes and tumor suppressors in the molecular pathogenesis of acute promyelocytic leukemia.Semantic proximity Read ↗

Leukemia initiated by PMLRARalpha: the PML domain plays a critical role while retinoic acid-mediated transactivation is dispensable.Semantic proximity Read ↗

Effects on differentiation by the promyelocytic leukemia PML/RARalpha protein depend on the fusion of the PML protein dimerization and RARalpha DNA binding domains.Semantic proximity Read ↗

Retinoic acid receptor fusion proteins: friend or foe.Semantic proximity Read ↗

Synergy against PML-RARa: targeting transcription, proteolysis, differentiation, and self-renewal in acute promyelocytic leukemiaSemantic proximity Read ↗

Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.