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Chromatin topology reorganization and transcription repression by PML-RARα in acute promyeloid leukemia

11 May 2020

Abstract excerpt

BACKGROUND: Acute promyeloid leukemia (APL) is characterized by the oncogenic fusion protein PML-RARα, a major etiological agent in APL. However, the molecular mechanisms underlying the role of PML-RARα in leukemogenesis remain largely unknown. RESULTS: Using an inducible system, we comprehensively analyze the 3D genome organization in myeloid cells and its reorganization after PML-RARα induction and perform...

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PMID: 32393309
DOI: 10.1186/s13059-020-02030-2

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