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Retinoic acid signaling in cancer: The parable of acute promyelocytic leukemia

14 Aug 2014

Abstract excerpt

Inevitably fatal some 40 years, acute promyelocytic leukemia (APL) can now be cured in more than 95% of cases. This clinical success story is tightly linked to tremendous progress in our understanding of retinoic acid (RA) signaling. The discovery of retinoic acid receptor alpha (RARA) was followed by the cloning of the chromosomal translocations driving APL, all of which involve RARA. Since then, new findings on...

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PMID: 25130873
DOI: 10.1002/ijc.29081

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