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Retinoic acid receptors, hematopoiesis and leukemogenesis

6 Jun 2008

Abstract excerpt

PURPOSE OF REVIEW: All-trans retinoic acid therapy of acute promyelocytic leukemia represents the most successful example of differentiation-induction therapy in clinical oncology. However, acute promyelocytic leukemia represents only a small minority (10-15%) of the myeloid leukemias. Recent studies provide significant insight into why some myeloid leukemias respond dramatically to all-trans retinoic acid...

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PMID: 18536573
DOI: 10.1097/moh.0b013e3283007edf

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