Article
[p53 gene mutation in hepatocellular carcinoma].
Zhonghua wai ke za zhi [Chinese journal of surgery] - 1 Sept 1998
Jiang W, Lu Q, Pan G
Abstract excerpt
OBJECTIVE: To study the relationship between mutation of p53 gene and hepatocellular carcinoma (HCC). METHOD: Sixty-five cases of HCC from Nanning prefecture of high aflatoxin (AFB1) exposure were studied by polymerase chain reaction and restrictive fragment length polymorphism (PCR-RFLP) analysis to examine the exon 7 of p53 gene in HCC. RESULT: 58.5% of the cases were found to show mutation at codon 249 of p53...
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