[Co-inactivation of the p53 and RB genes in human hepato cellular carcinoma].

Article

[Co-inactivation of the p53 and RB genes in human hepato cellular carcinoma].

Nihon rinsho. Japanese journal of clinical medicine - 1 Feb 1993

Murakami Y

Abstract excerpt

Aberrations of the p53 gene were observed in high frequency in HCCs in China, Mozambique and Japan. Most of the mutations were G to T transversions in codon 249 of the p53 gene in HCCs in China and Mozambique, where aflatoxin B1 was a risk factor. These findings strongly suggest that aflatoxin B1...

Topics

Aflatoxin B1
Animals
Carcinoma, Hepatocellular
Chromosome Aberrations
Gene Deletion
Genes, Retinoblastoma
Genes, p53
Heterozygote
Humans
Liver Neoplasms
Liver Neoplasms, Experimental
Mutation
Polymorphism, Restriction Fragment Length
Risk Factors

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