Article
The p53 mutation spectrum in hepatocellular carcinoma from Guangxi, China : role of chronic hepatitis B virus infection and aflatoxin B1 exposure.
Liver international : official journal of the International Association for the Study of the Liver - 1 Mar 2015
Qi Lu-Nan, Bai Tao, Chen Zu-Shun, Wu Fei-Xiang, Chen Yuan-Yuan, De Xiang Bang-, Peng Tao, Han Ze-Guang, Li Le-Qun
Abstract excerpt
BACKGROUND & AIMS: p53 is one of the most frequently mutated human tumour suppressor genes. Chronic infection with hepatitis B virus (HBV) and exposure to aflatoxin B1 (AFB1) induces p53 mutations in hepatocellular carcinoma (HCC) tissue. The aims of present study are to investigate the p53 mutation spectrum in HBV- and AFB1-related hepatocarcinogenesis in patients with hepatocellular carcinoma (HCC) in Guangxi,...
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