Article
Mutations of p53 gene in hepatocellular carcinoma: roles of hepatitis B virus and aflatoxin contamination in the diet.
Journal of the National Cancer Institute - 4 Nov 1992
Hsia C C, Kleiner D E, Axiotis C A, Di Bisceglie A, Nomura A M, Stemmermann G N, Tabor E
Abstract excerpt
BACKGROUND: Mutations of the p53 tumor suppressor gene have been reported in 50% of patients with hepatocellular carcinoma (HCC) from China and South Africa. These reports suggested an association of p53 mutations with high levels of aflatoxin in the diet. Most studies of p53 and HCC, however, have not fully evaluated the possible role of the hepatitis B virus (HBV). Aflatoxin is a substance produced by food mold...
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