Article
The mouse meiotic mutation mei1 disrupts chromosome synapsis with sexually dimorphic consequences for meiotic progression.
Developmental biology - 15 Feb 2002
Libby Brian J, De La Fuente Rabindranath, O'Brien Marilyn J, Wigglesworth Karen, Cobb John, Inselman Amy, Eaker Shannon, Handel Mary Ann, Eppig John J, Schimenti John C
Abstract excerpt
mei1 (meiosis defective 1) is the first meiotic mutation in mice derived by phenotype-driven mutagenesis. It was isolated by using a novel technology in which embryonic stem (ES) cells were chemically mutagenized and used to generate families of mice that were screened for infertility. We report here that mei1/mei1 spermatocytes arrest at the zygotene stage of meiosis I, exhibiting failure of homologous...
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