Article
Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic crossing over.
PLoS genetics - 1 Aug 2007
Ward Jeremy O, Reinholdt Laura G, Motley William W, Niswander Lisa M, Deacon Dekker C, Griffin Laurie B, Langlais Kristofor K, Backus Vickie L, Schimenti Kerry J, O'Brien Marilyn J, Eppig John J, Schimenti John C
Abstract excerpt
Crossing over during meiotic prophase I is required for sexual reproduction in mice and contributes to genome-wide genetic diversity. Here we report on the characterization of an N-ethyl-N-nitrosourea-induced, recessive allele called mei4, which causes sterility in both sexes owing to meiotic defects. In mutant spermatocytes, chromosomes fail to congress properly at the metaphase plate, leading to arrest and...
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