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Article

A-MYB (MYBL1) transcription factor is a master regulator of male meiosis.

Development (Cambridge, England) - 1 Aug 2011

Bolcun-Filas Ewelina, Bannister Laura A, Barash Alex, Schimenti Kerry J, Hartford Suzanne A, Eppig John J, Handel Mary Ann, Shen Lishuang, Schimenti John C

Abstract excerpt

The transcriptional regulation of mammalian meiosis is poorly characterized, owing to few genetic and ex vivo models. From a genetic screen, we identify the transcription factor MYBL1 as a male-specific master regulator of several crucial meiotic processes. Spermatocytes bearing a novel separation-of-function allele (Mybl1(repro9)) had subtle defects in autosome synapsis in pachynema, a high incidence of...

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Source

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Identifiers

PMID: 21750041
DOI: 10.1242/dev.067645
PMCID: PMC3133921

Genes

MYBL1
MYB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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