Article
JunB can substitute for Jun in mouse development and cell proliferation.
Nature genetics - 1 Feb 2002
Passegué Emmanuelle, Jochum Wolfram, Behrens Axel, Ricci Romeo, Wagner Erwin F
Abstract excerpt
The Jun and JunB components of the AP-1 transcription factor are known to have antagonistic functions. Here we show, by a knock-in strategy and a transgenic complementation approach, that Junb can substitute for absence of Jun during mouse development. Junb can rescue both liver and cardiac defects in Jun-null mice in a manner dependent on gene dosage. JunB restores the expression of genes regulated by Jun/Fos,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.