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Article

Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects.

The Journal of cell biology - 16 Feb 2004

Kenner Lukas, Hoebertz Astrid, Beil F Timo, Beil Timo, Keon Niamh, Karreth Florian, Eferl Robert, Scheuch Harald, Szremska Agnieszka, Amling Michael, Schorpp-Kistner Marina, Angel Peter, Wagner Erwin F

Abstract excerpt

Because JunB is an essential gene for placentation, it was conditionally deleted in the embryo proper. JunBDelta/Delta mice are born viable, but develop severe low turnover osteopenia caused by apparent cell-autonomous osteoblast and osteoclast defects before a chronic myeloid leukemia-like disease. Although JunB was reported to be a negative regulator of cell proliferation, junBDelta/Delta osteoclast precursors...

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Bone and Bones
Bone Diseases, Metabolic
Cell Division
Cell Lineage
Osteoblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins c-jun

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PMID: 14769860
DOI: 10.1083/jcb.200308155
PMCID: PMC2171977

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