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Article

Role of JunB in erythroid differentiation.

The Journal of biological chemistry - 15 Feb 2002

Jacobs-Helber Sarah M, Abutin Randolph M, Tian Cuixia, Bondurant Maurice, Wickrema Amittha, Sawyer Stephen T

Abstract excerpt

The role of junB as a regulator of erythroid cell survival, proliferation, and differentiation was tested by controlled expression of JunB in the erythropoietin (EPO)-dependent erythroleukemia cell line HCD57. JunB induced erythroid differentiation as evidenced by increased expression of the erythroid-specific proteins beta-globin, spectrin-alpha, and TER-119. Expression of JunB for at least 48 h was required for...

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Source

Identifiers

PMID: 11726656
DOI: 10.1074/jbc.M107243200

Genes

EPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

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Role of JunB in erythroid differentiation.PMID 11726656Read ↗

Constitutive JunB expression, associated with the JAK2 V617F mutation, stimulates proliferation of the erythroid lineageSemantic proximity Read ↗

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JunB is essential for mammalian placentation.Semantic proximity Read ↗

JunB can substitute for Jun in mouse development and cell proliferation.Semantic proximity Read ↗

Defective endochondral ossification in mice with strongly compromised expression of JunB.Semantic proximity Read ↗

Functions of c-Jun in Liver and Heart DevelopmentSemantic proximity Read ↗

The expression levels of JunB, JunD and p-c-Jun are positively correlated with tumor cell proliferation in diffuse large B-cell lymphomas.Semantic proximity Read ↗

JunB inhibits proliferation and transformation in B-lymphoid cellsSemantic proximity Read ↗

JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta CellsSemantic proximity Read ↗

Targeted disruption of the murine junD gene results in multiple defects in male reproductive function.Semantic proximity Read ↗

Cell cycle-dependent variations in c-Jun and JunB phosphorylation: a role in the control of cyclin D1 expression.Semantic proximity Read ↗

EPO modulation of cell-cycle regulatory genes, and cell division, in primary bone marrow erythroblasts.Semantic proximity Read ↗

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