Somatic mutations acquired during life: state of the art and implications for the kidney.

Abstract excerpt

As a consequence of continuous interaction with mutagens, the genome sequence accumulates changes, which are referred to as somatic mutations. Somatic variants acquired by normal cells during a lifetime are difficult to detect with common sequencing methods. This review provides a basic description of currently available technologies for somatic mutation detection and summarizes the studies that have explored...

Topics

• Humans
• Mutation
• Kidney
• Kidney Neoplasms
• Aristolochic Acids
• DNA Mutational Analysis
• Genetic Predisposition to Disease