Article

Systemic mutagen exposures reported by normal kidney cell genomes

2026-04-09

Abstract excerpt

Lifestyle, environmental and other exposures to exogenous mutagens generate somatic mutations in normal human cells in vivo and increase cancer risk. However, the global repertoire of exogenous mutagen exposures is uncertain. The mutational signatures of mutagens in normal tissues offer opportunities to detect such exposures and survey them at population level. Using single-molecule duplex sequencing of normal ki...

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Literature Corpus work: cc3585c0-2222-56c0-a978-0f87bf34152c
DOI: 10.64898/2026.04.07.716715

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