Article
RNA helicase MUT-14-dependent gene silencing triggered in C. elegans by short antisense RNAs.
Science (New York, N.Y.) - 25 Jan 2002
Tijsterman Marcel, Ketting René F, Okihara Kristy L, Sijen Titia, Plasterk Ronald H A
Abstract excerpt
Posttranscriptional gene silencing in Caenorhabditis elegans results from exposure to double-stranded RNA (dsRNA), a phenomenon designated as RNA interference (RNAi), or from co-suppression, in which transgenic DNA leads to silencing of both the transgene and the endogenous gene. Here we show that single-stranded RNA oligomers of antisense polarity can also be potent inducers of gene silencing. As is the case for...
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