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Article

Sequence-specific inhibition of small RNA function.

PLoS biology - 1 Apr 2004

Hutvágner György, Simard Martin J, Mello Craig C, Zamore Phillip D

Abstract excerpt

Hundreds of microRNAs (miRNAs) and endogenous small interfering RNAs (siRNAs) have been identified from both plants and animals, yet little is known about their biochemical modes of action or biological functions. Here we report that 2'-O-methyl oligonucleotides can act as irreversible, stoichiometric inhibitors of small RNA function. We show that a 2'-O-methyl oligonucleotide complementary to an siRNA can block...

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Identifiers

PMID: 15024405
DOI: 10.1371/journal.pbio.0020098
PMCID: PMC350664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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