Article
Targeting Functional Noncoding RNAs.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017
Crossley Madzia P, Krude Torsten
Abstract excerpt
Noncoding RNAs have essential biochemical functions in different areas of cellular metabolism, including protein synthesis, RNA splicing, protein secretion, and DNA replication. We have successfully used Morpholino antisense oligonucleotides for the functional inactivation of small noncoding RNAs required for DNA replication (Y RNAs in vertebrates and stem-bulge RNAs in nematodes). Here we discuss specific issues...
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