Article
RNAi (Nematodes: Caenorhabditis elegans).
Advances in genetics - 1 Jan 2002
Grishok Alla, Mello Craig C
Abstract excerpt
RNA interference in Caenorhabditis elegans is a type of homology dependent posttranscriptional gene silencing induced by dsRNA. In this chapter we describe the history of the discovery of RNAi, its systemic nature, inheritance, and connection to other homology-dependent silencing phenomena like co-suppression and transcriptional gene silencing. We discuss RNAi-deficient mutants in C. elegans as well as...
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