Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The double-stranded RNA binding protein RDE-4 can act cell autonomously during feeding RNAi in C. elegans.

Nucleic acids research - 21 Aug 2017

Raman Pravrutha, Zaghab Soriayah M, Traver Edward C, Jose Antony M

Abstract excerpt

Long double-stranded RNA (dsRNA) can silence genes of matching sequence upon ingestion in many invertebrates and is therefore being developed as a pesticide. Such feeding RNA interference (RNAi) is best understood in the worm Caenorhabditis elegans, where the dsRNA-binding protein RDE-4 initiates silencing by recruiting an endonuclease to process long dsRNA into short dsRNA. These short dsRNAs are thought to move...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to RNA-Binding Proteins

Share to RNA, Double-Stranded

Share to RNA, Helminth

Share to RNA Interference

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 28541563
DOI: 10.1093/nar/gkx484
PMCID: PMC5737277

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The double-stranded RNA binding protein RDE-4 can act cell autonomously during feeding RNAi in C. elegans.PMID 28541563Read ↗

Gene silencing by double-stranded RNA from <i>C. elegans</i> neurons reveals functional mosaicism of RNA interferenceSemantic proximity Read ↗

The rde-1 gene, RNA interference, and transposon silencing in C. elegans.Semantic proximity Read ↗

Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans.Semantic proximity Read ↗

Distinct roles for RDE-1 and RDE-4 during RNA interference in Caenorhabditis elegans.Semantic proximity Read ↗

A pre- and co-knockdown of RNAseT enzyme, Eri-1, enhances the efficiency of RNAi induced gene silencing in Caenorhabditis elegans.Semantic proximity Read ↗

Inducible systemic RNA silencing in Caenorhabditis elegans.Semantic proximity Read ↗

Target-specific requirements for RNA interference can arise through restricted RNA amplification despite the lack of specialized pathwaysSemantic proximity Read ↗

A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans.Semantic proximity Read ↗

Tissue specificity of Caenorhabditis elegans enhanced RNA interference mutants.Semantic proximity Read ↗

RNAi mechanisms in Caenorhabditis elegans.Semantic proximity Read ↗

Gene expression: long-term gene silencing by RNAi.Semantic proximity Read ↗

Distinct phases of siRNA synthesis in an endogenous RNAi pathway in C. elegans soma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.