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Article

Distinct phases of siRNA synthesis in an endogenous RNAi pathway in C. elegans soma.

Molecular cell - 12 Mar 2010

Gent Jonathan I, Lamm Ayelet T, Pavelec Derek M, Maniar Jay M, Parameswaran Poornima, Tao Li, Kennedy Scott, Fire Andrew Z

Abstract excerpt

Endogenous RNA-directed RNA polymerases (RdRPs) are cellular components capable of synthesizing new complementary RNAs from existing RNA templates. We present evidence for successive engagement of two different RdRPs in an endogenous siRNA-based mechanism targeting specific mRNAs in C. elegans soma. In the initiation stage of this process, a group of mRNA species are chosen as targets for downregulation, leading...

Topics

Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Eukaryotic Initiation Factors
Exoribonucleases
Mutation
Phosphorylation
RNA Interference
RNA Stability
RNA, Messenger

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Small Interfering

RNA-Binding Proteins

RNA-Dependent RNA Polymerase

Ribonuclease III

Transcription, Genetic

Source

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Identifiers

PMID: 20116306
DOI: 10.1016/j.molcel.2010.01.012
PMCID: PMC2838994

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