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Article

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.

Nature - 19 Feb 1998

Fire A, Xu S, Montgomery M K, Kostas S A, Driver S E, Mello C C

Abstract excerpt

Experimental introduction of RNA into cells can be used in certain biological systems to interfere with the function of an endogenous gene. Such effects have been proposed to result from a simple antisense mechanism that depends on hybridization between the injected RNA and endogenous messenger RNA transcripts. RNA interference has been used in the nematode Caenorhabditis elegans to manipulate gene expression....

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PMID: 9486653
DOI: 10.1038/35888

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