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Article

Genetic variation in CYP2A6-mediated nicotine metabolism alters smoking behavior.

Therapeutic drug monitoring - 1 Feb 2002

Tyndale Rachel F, Sellers Edward M

Abstract excerpt

Approximately 50% of the initiation of tobacco dependence is genetically influenced, whereas maintenance of dependent smoking behavior and amount smoked have approximately 70% genetic contribution (1-5). Determining the variation in nicotine's inactivation is important because of nicotine's role in producing tobacco dependence and regulating smoking patterns (6-11). The genetically polymorphic CYP2A6 enzyme is...

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Source

Identifiers

PMID: 11805739
DOI: 10.1097/00007691-200202000-00026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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