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Article

A common genetic defect in nicotine metabolism decreases risk for dependence and lowers cigarette consumption.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco - 1 Jan 1999

Tyndale R F, Pianezza M L, Sellers E M

Abstract excerpt

Nicotine is the primary compound present in tobacco that is responsible for establishing and maintaining tobacco dependence; dependent smokers adjust their smoking behavior to maintain peripheral and central nicotine levels. CYP2A6 is the enzyme responsible for the majority of the inactivation of nicotine in humans. This enzyme is also responsible for activating tobacco-related procarcinogens such as the...

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Source

Identifiers

PMID: 11768189
DOI: 10.1080/14622299050011831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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