Article

Hydrogen peroxide formation by Nox4 limits malignant transformation

2017-08-16

Abstract excerpt

Reactive oxygen species (ROS) can cause cellular damage and are thought to promote cancer-development. Nevertheless, under physiological conditions, all cells constantly produce ROS, either as chemical by-products or for signaling purpose. During differentiation cells induce the NADPH oxidase Nox4, which constitutively produces low amounts of H 2 O 2 . We infer that this constitutive H 2 O 2 is unlikely to be...

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Literature Corpus work: ca73501f-f865-54b3-b41f-76e316649b5d
DOI: 10.1101/177055

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