Article
The Cytosolic NADPH Oxidase Subunit NoxO1 Promotes an Endothelial Stalk Cell Phenotype.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2016
Brandes Ralf P, Harenkamp Sabine, Schürmann Christoph, Josipovic Ivana, Rashid Beliza, Rezende Flavia, Löwe Oliver, Moll Franziska, Epah Jeremy, Eresch Jeanette, Nayak Arnab, Kopaliani Irakli, Penski Cornelia, Mittelbronn Michel, Weissmann Norbert, Schröder Katrin
Abstract excerpt
OBJECTIVE: Reactive oxygen species generated by nicotinamide adenine dinucleotide phosphate (NADPH) oxidases contribute to angiogenesis and vascular repair. NADPH oxidase organizer 1 (NoxO1) is a cytosolic protein facilitating assembly of constitutively active NADPH oxidases. We speculate that NoxO1 also contributes to basal reactive oxygen species formation in the vascular system and thus modulates angiogenesis....
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