Article
The role of angiogenesis in tumor growth.
Seminars in cancer biology - 1 Apr 1992
Folkman J
Abstract excerpt
Experimental and clinical evidence is here assembled in support of the concept that the development of a solid tumor progresses from a prevascular phase to a vascular phase. The prevascular tumor does not induce angiogenesis, is limited in size, and rarely metastasizes. The vascularized tumor induces host microvessels to undergo angiogenesis, has the potential to rapidly expand its cell population, and has a...
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