Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypoxia, Clonal Selection, and the Role of HIF-1 in Tumor Progression

1 Jan 2000

Abstract excerpt

Tumor progression occurs as a result of the clonal selection of cells in which somatic mutations have activated oncogenes or inactivated tumor suppressor genes leading to increased proliferation and/or survival within the hypoxic tumor microenvironment. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates adaptive responses to reduced O2 availability, including angiogenesis and glycolysis....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Cancer-related Molecular Pathways
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10821478
DOI: 10.1080/10409230091169186

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypoxia, Clonal Selection, and the Role of HIF-1 in Tumor ProgressionPMID 10821478Read ↗

Hypoxia‐inducible factor 1 and cancer pathogenesisSemantic proximity Read ↗

Expression of hypoxia-inducible factor 1: mechanisms and consequencesSemantic proximity Read ↗

A gene for all seasons: The evolutionary consequences of HIF-1 in carcinogenesis, tumor growth and metastasisSemantic proximity Read ↗

HIF-1α Confers Aggressive Malignant Traits on Human Tumor Cells Independent of Its Canonical Transcriptional FunctionSemantic proximity Read ↗

Hypoxia-inducible factors: cancer progression and clinical translationSemantic proximity Read ↗

Hypoxia‐inducible factor‐1 and oncogenic signallingSemantic proximity Read ↗

Hypoxia inducible factor-2alpha: a critical mediator of aggressive tumor phenotypes.Semantic proximity Read ↗

Hypoxia-inducible factors: central regulators of the tumor phenotype.Semantic proximity Read ↗

Investigating hypoxia-inducible factor signaling in cancer: Mechanisms, clinical implications, targeted therapeutic strategies, and resistanceSemantic proximity Read ↗

Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunitySemantic proximity Read ↗

HIF-1 — A BIG CHAPTER IN THE CANCER TALESemantic proximity Read ↗

Targeting Tumor Adaption to Chronic Hypoxia: Implications for Drug Resistance, and How It Can Be OvercomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.