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Article

NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction.

The Journal of biological chemistry - 12 May 2017

Juhasz Agnes, Markel Susan, Gaur Shikha, Liu Han, Lu Jiamo, Jiang Guojian, Wu Xiwei, Antony Smitha, Wu Yongzhong, Melillo Giovanni, Meitzler Jennifer L, Haines Diana C, Butcher Donna, Roy Krishnendu, Doroshow James H

Abstract excerpt

Reactive oxygen species (ROS) play a critical role in cell signaling and proliferation. NADPH oxidase 1 (NOX1), a membrane-bound flavin dehydrogenase that generates O2̇̄, is highly expressed in colon cancer. To investigate the role that NOX1 plays in colon cancer growth, we used shRNA to decrease NOX1 expression stably in HT-29 human colon cancer cells. The 80-90% decrease in NOX1 expression achieved by RNAi...

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Identifiers

PMID: 28330872
DOI: 10.1074/jbc.M116.768283
PMCID: PMC5427267

Genes

NOX1
MYB
MYC

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