Article
Switch to the angiogenic phenotype during tumorigenesis.
Princess Takamatsu symposia - 1 Jan 1991
Folkman J, Hanahan D
Abstract excerpt
Tumor growth and metastasis are angiogenesis-dependent. Virtually all solid tumors are neovascularized by the time they are detected. However, there is a prevascular phase during early tumor development where few or no tumor cells are angiogenic and expansion of the tumor is restricted to a few mm3. When enough tumor cells become angiogenic, the tumor can expand progressively and shed metastatic cells. This...
Topics
- Animals
- Down-Regulation
- Genes, Suppressor
- Humans
- Neoplasms
- Neovascularization, Pathologic
- Phenotype