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Article

Methylcholanthrene-Induced Sarcomas Develop Independently from NOX2-Derived ROS.

PloS one - 1 Jan 2015

Ligtenberg Maarten A, Çınar Özcan, Holmdahl Rikard, Mougiakakos Dimitrios, Kiessling Rolf

Abstract excerpt

Reactive oxygen species (ROS) produced by the inducible NADPH oxidase type 2 (NOX2) complex are essential for clearing certain infectious organisms but may also have a role in regulating inflammation and immune response. For example, ROS is involved in myeloid derived suppressor cell (MDSC)- and regulatory T cell (T(reg)) mediated T- and NK-cell suppression. However, abundant ROS produced within the tumor...

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Source

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Identifiers

PMID: 26076008
DOI: 10.1371/journal.pone.0129786
PMCID: PMC4468117

Genes

NCF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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