Basolateral sorting of the coxsackie and adenovirus receptor through interaction of a canonical YXXPhi motif with the clathrin adaptors AP-1A and AP-1B.

doi:10.1073/pnas.1117949109

Article

Basolateral sorting of the coxsackie and adenovirus receptor through interaction of a canonical YXXPhi motif with the clathrin adaptors AP-1A and AP-1B.

Proceedings of the National Academy of Sciences of the United States of America - 6 Mar 2012

Carvajal-Gonzalez Jose Maria, Gravotta Diego, Mattera Rafael, Diaz Fernando, Perez Bay Andres, Roman Angel C, Schreiner Ryan P, Thuenauer Roland, Bonifacino Juan S, Rodriguez-Boulan Enrique

Abstract excerpt

The coxsackie and adenovirus receptor (CAR) plays key roles in epithelial barrier function at the tight junction, a localization guided in part by a tyrosine-based basolateral sorting signal, (318)YNQV(321). Sorting motifs of this type are known to route surface receptors into clathrin-mediated endocytosis through interaction with the medium subunit (μ2) of the clathrin adaptor AP-2, but how they guide new and...

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Basolateral sorting of the coxsackie and adenovirus receptor through interaction of a canonical YXXPhi motif with the clathrin adaptors AP-1A and AP-1B.

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