Article
The tyrosine-based lysosomal targeting signal in lamp-1 mediates sorting into Golgi-derived clathrin-coated vesicles.
The EMBO journal - 1 Oct 1996
Höning S, Griffith J, Geuze H J, Hunziker W
Abstract excerpt
Diversion of membrane proteins from the trans-Golgi network (TGN) or the plasma membrane into the endosomal system occurs via clathrin-coated vesicles (CCVs). These sorting events may require the interaction of cytosolic domain signals with clathrin adaptor proteins (APs) at the TGN (AP-1) or the plasma membrane (AP-2). While tyrosine- and di-leucine-based signals in several proteins mediate endocytosis via cell...
Topics
- Adaptor Protein Complex alpha Subunits
- Adaptor Proteins, Vesicular Transport
- Animals
- Antigens, CD
- Biological Transport
- Brain Chemistry
- Cell Line
- Coated Vesicles
- Cytosol
- Dogs
- Endosomes
- Golgi Apparatus
- Intracellular Membranes
- Lysosomal Membrane Proteins