Article
The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane.
The Journal of cell biology - 1 Feb 1996
Rohrer J, Schweizer A, Russell D, Kornfeld S
Abstract excerpt
Lamp1 is a type I transmembrane glycoprotein that is localized primarily in lysosomes and late endosomes. Newly synthesized molecules are mostly transported from the trans-Golgi network directly to endosomes and then to lysosomes. A minor pathway involves transport via the plasma membrane. The 11...
Topics
- Amino Acid Sequence
- Animals
- Antigens, CD
- Biological Transport
- Cell Line
- Cell Membrane
- Gene Transfer Techniques
- Lysosomal-Associated Membrane Protein 1
- Lysosomal Membrane Proteins
- Lysosomes
- Membrane Glycoproteins
- Mice
- Microscopy, Electron
- Molecular Sequence Data
- Mutation
- Sequence Analysis
- Tyrosine