Article
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
Molecular biology of the cell - 1 Sept 2005
Janvier Katy, Bonifacino Juan S
Abstract excerpt
The limiting membrane of the lysosome contains a group of transmembrane glycoproteins named lysosome-associated membrane proteins (Lamps). These proteins are targeted to lysosomes by virtue of tyrosine-based sorting signals in their cytosolic tails. Four adaptor protein (AP) complexes, AP-1, AP-2, AP-3, and AP-4, interact with such signals and are therefore candidates for mediating sorting of the Lamps to...
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