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Lysosomal and vacuolar sorting: not so different after all!

9 Jun 2016

Abstract excerpt

Soluble hydrolases represent the main proteins of lysosomes and vacuoles and are essential to sustain the lytic properties of these organelles typical for the eukaryotic organisms. The sorting of these proteins from ER residents and secreted proteins is controlled by highly specific receptors to avoid mislocalization and subsequent cellular damage. After binding their soluble cargo in the early stage of the...

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PMID: 27284057
DOI: 10.1042/bst20160050

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