Article
Mechanism of interaction between leucine-based sorting signals from the invariant chain and clathrin-associated adaptor protein complexes AP1 and AP2.
The Journal of biological chemistry - 10 May 2002
Kongsvik Thomas L, Höning Stefan, Bakke Oddmund, Rodionov Dmitrii G
Abstract excerpt
The cytoplasmic tail of the invariant chain contains two leucine-based sorting signals, and each of those seems sufficient to route the invariant chain to its intracellular destination in either normal or polarized cells. It is believed that the intracellular routing of the invariant chain is mediated by its interactions with the clathrin-associated adaptor protein complexes AP1 and AP2. We () have previously...
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