Use of exact and adjusted liability scores to detect genes affecting common traits.

doi:10.1002/gepi.1370120639

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Article

Use of exact and adjusted liability scores to detect genes affecting common traits.

Genetic epidemiology - 1 Jan 1995

Goldin L R, Chase G A, King T M, Badner J A, Gershon E S

Abstract excerpt

We used the Haseman-Elston sib-pair test to screen for linkage of markers to genes for disease susceptibility in the simulated data as given in Problem 2 of GAW9. We applied the analysis to the underlying quantitative liability trait (Q1), other covariates of Q1 (Q2-Q4), and the dichotomous affec...

Topics

Analysis of Variance
Chromosome Mapping
Genetic Diseases, Inborn
Genetic Markers
Genetic Predisposition to Disease
Genetic Testing
Humans
Nuclear Family
Phenotype
Regression Analysis

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