Article
Multiple phenotype modeling in gene-mapping studies of quantitative traits: power advantages.
American journal of human genetics - 1 Oct 1998
Allison D B, Thiel B, St Jean P, Elston R C, Infante M C, Schork N J
Abstract excerpt
Genomewide searches for loci influencing complex human traits and diseases such as diabetes, hypertension, and obesity are often plagued by low power and interpretive difficulties. Attempts to remedy these difficulties have typically relied on, and have promoted the use of, novel subject-ascertainment schemes, larger sample sizes, a greater density of DNA markers, and more-sophisticated statistical modeling and...
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