Article

PDGFRα signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal trafficking

2024-04-03

Abstract excerpt

Signaling through the platelet-derived growth factor receptor alpha (PDGFRα) plays a critical role in craniofacial development, as mutations in PDGFRA are associated with cleft lip/palate in humans and Pdgfra mutant mouse models display varying degrees of facial clefting. Phosphatidylinositol 3-kinase (PI3K)/Akt is the primary effector of PDGFRα signaling during skeletal development in the mouse. We previously d...

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Literature Corpus work: 4563e59a-c934-5c87-9a7a-354ea9b7ac94
DOI: 10.1101/2024.04.03.587975

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