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Article

A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling.

Nature genetics - 1 Oct 2004

Ding Hao, Wu Xiaoli, Boström Hans, Kim Injune, Wong Nicole, Tsoi Bonny, O'Rourke Meredith, Koh Gou Young, Soriano Philippe, Betsholtz Christer, Hart Thomas C, Marazita Mary L, Field L L, Tam Patrick P L, Nagy Andras

Abstract excerpt

PDGF-C is a member of the platelet-derived growth factor (PDGF) family, which signals through PDGF receptor (PDGFR) alphaalpha and alphabeta dimers. Here we show that Pdgfc(-/-) mice die in the perinatal period owing to feeding and respiratory difficulties associated with a complete cleft of the secondary palate. This phenotype was less severe than that of Pdgfra(-/-) embryos. Pdgfc(-/-) Pdgfa(-/-) embryos...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15361870
DOI: 10.1038/ng1415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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