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A human YAC transgene rescues craniofacial and neural tube development inPDGFRα knockout mice and uncovers a role for PDGFRα in prenatal lung growth

1 Nov 2000

Abstract excerpt

The platelet-derived growth factor alpha-receptor (PDGFRalpha) plays a vital role in the development of vertebrate embryos, since mice lacking PDGFRalpha die in mid-gestation. PDGFRalpha is expressed in several types of migratory progenitor cells in the embryo including cranial neural crest cells, lung smooth muscle progenitors and oligodendrocyte progenitors. To study PDGFRalpha gene regulation and function...

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PMID: 11023856
DOI: 10.1242/dev.127.21.4519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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