Article

Dandy Walker-like malformations in mutant mice demonstrate a role for PDGF-C/PDGFRα signalling in cerebellar development

2022-05-13

Abstract excerpt

Formation of the mouse cerebellum is initiated in the embryo and continues for a few weeks after birth. Double mutant mice lacking platelet-derived growth factor-C and that are heterozygous for platelet-derived growth factor receptor alpha ( Pdgfc-/-; Pdgfra GFP/+ ) develop cerebellar hypoplasia and malformation with loss of cerebellar lobes in the posterior vermis. This phenotype is similar to those observed in...

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Literature Corpus work: 314a9465-ed43-57d9-8019-d83ac60eac1f
DOI: 10.1101/2022.05.13.491787

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