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Article

Evolutionary divergence of platelet-derived growth factor alpha receptor signaling mechanisms.

Molecular and cellular biology - 1 Jun 2003

Hamilton T Guy, Klinghoffer Richard A, Corrin Philip D, Soriano Philippe

Abstract excerpt

Receptor tyrosine kinases (RTKs) direct diverse cellular and developmental responses by stimulating a relatively small number of overlapping signaling pathways. Specificity may be determined by RTK expression patterns or by differential activation of individual signaling pathways. To address this issue we generated knock-in mice in which the extracellular domain of the mouse platelet-derived growth factor alpha...

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Identifiers

PMID: 12748302
DOI: 10.1128/MCB.23.11.4013-4025.2003
PMCID: PMC155222

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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