Article
Rescue of cardiomyopathy in peroxisome proliferator-activated receptor-alpha transgenic mice by deletion of lipoprotein lipase identifies sources of cardiac lipids and peroxisome proliferator-activated receptor-alpha activators.
Circulation - 26 Jan 2010
Duncan Jennifer G, Bharadwaj Kalyani G, Fong Juliet L, Mitra Riddhi, Sambandam Nandakumar, Courtois Michael R, Lavine Kory J, Goldberg Ira J, Kelly Daniel P
Abstract excerpt
BACKGROUND: Emerging evidence in obesity and diabetes mellitus demonstrates that excessive myocardial fatty acid uptake and oxidation contribute to cardiac dysfunction. Transgenic mice with cardiac-specific overexpression of the fatty acid-activated nuclear receptor peroxisome proliferator-activated receptor-alpha (myosin heavy chain [MHC]-PPARalpha mice) exhibit phenotypic features of the diabetic heart, which...
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