Article
MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet.
Cardiovascular diabetology - 5 Aug 2015
He Jun, Quintana Megan T, Sullivan Jenyth, L Parry Traci, J Grevengoed Trisha, Schisler Jonathan C, Hill Joseph A, Yates Cecelia C, Mapanga Rudo F, Essop M Faadiel, Stansfield William E, Bain James R, Newgard Christopher B, Muehlbauer Michael J, Han Yipin, Clarke Brian A, Willis Monte S
Abstract excerpt
BACKGROUND: In diabetes mellitus the morbidity and mortality of cardiovascular disease is increased and represents an important independent mechanism by which heart disease is exacerbated. The pathogenesis of diabetic cardiomyopathy involves the enhanced activation of PPAR transcription factors, including PPARα, and to a lesser degree PPARβ and PPARγ1. How these transcription factors are regulated in the heart is...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.